![]() ![]() Importantly, we provide in vivo evidence for such modulation that may cause an alteration in drug disposition. In conclusion, IRIP negatively modulates the function of OCT1 and MATE1 in cells. In addition, we observed that the expression of IRIP was approximately half (P < 0.01) in ob/ob mice when compared to their lean littermates, with significant increases in hepatic Oct1 protein expression and metformin accumulation. By overexpressing IRIP in mouse liver via hydrodynamic tail vein injection, we demonstrated that increased IRIP expression could cause a significant reduction in hepatic accumulation of metformin (P < 0.01). IRIP overexpression decreased the membrane localization of transporter proteins without any changes in transcript levels in cells. Log in to manage upgrades, follow changes, view knowledge content, and more. In contrast, knockdown of IRIP by small hairpin RNA (shRNA) increased the transporter activities in vitro. The Now Support portal is your launchpad to access self-help, get technical support, and manage your ServiceNow instances. The clade support from the alternative Bayesian phylogeny (1.000.000 generations) is shown together. Chat is a great option for quick ‘how to’ and non-complex issues or questions. Irip support software#In the uptake studies in the human embryonic kidney 293 cells overexpressing IRIP with and without OCT1 or MATE1, IRIP overexpression was found to significantly inhibit the uptake of 1-methyl-4-phenylpyridinium mediated by OCT1 or MATE1. distachyon IRIP homologs based on 100 bootstrap replicates. In order to best help and support you, we never stop looking for ways to improve your software user experience. The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug for diabetes and other obesity-related syndromes. The recently identified ischemia/reperfusion-inducible protein (IRIP) has been reported to negatively modulate the activities of several transporters in cell culture systems. ![]()
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